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Regimen, Duration and Dosage for Isoniazid [H] Mono/Poly DR-TB Regimen
Learning ObjectivesRegimen, Duration and Dosage for Isoniazid [H] Mono/Poly DR-TB Regimen
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Isoniazid (H) mono/ poly Drug-resistant TB (DR-TB) regimen has the following regimen, duration and dosage of drugs.
Regimen: (6 or 9) Lfx R E Z
Dosage
- The dosage of drugs would vary as per the weight of the patients.
- Adult patients (≥ 18 years) would be classified in weight bands of <16 kg, 16-29 kg, 30-45 kg, 46-70 kg and 70 kg. The drug dosages by these weight bands are shown in the table below.
- All drugs in the regimen are to be given on a daily basis under observation.
| SR. NO | DRUGS | 16-29 KG | 30-45 KG | 46-70 KG | >70 KG |
|---|---|---|---|---|---|
| 1 | Rifampicin (R) | 300 mg | 450 mg | 600 mg | 750 mg |
| 2 | Ethambutol (E) | 400 mg | 800 mg | 1200 mg | 1600 mg |
| 3 | Pyrazinamide (Z) | 750 mg | 1250 mg | 1750 mg | 2000 mg |
| 4 | Levofloxacin (Lfx) | 250 mg | 750 mg | 1000 mg | 1000 mg |
Duration
- H mono/ poly DR-TB regimen is for 6 or 9 months with no separate Intensive Phase (IP)/ Continuation Phase (CP).
- In exceptional situations of unavailability of loose drug R or E or Z, the use of 4 FDC (HREZ) with Levofloxacin (Lfx) loose tablets may be considered as an option rather than not starting the H mono/ poly DR-TB patients on treatment.
Resources
- Guidelines for Programmatic Management of Drug-resistant Tuberculosis in India, March 2021.
- WHO Consolidated Guidelines on Tuberculosis: Module 4 - Treatment: Drug-resistant TB Treatment, 2020.
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